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Abstract
A type of dosage form (similar to the liposomal drug delivery system), w/o/w liquid membrane capsular delivery system, has been developed for controlling the drug release. Chlorpheniramine maleate was used as a model drug. Extensive work was planned and meticulously executed for evolving a stabilization process of the designed multiple emulsion. The problem was tackled from different angles such as choice of emulsifier and viscosity builder and their concentrations, the HLB values of the emulsifiers, phase volume ratio both in case of primary emulsification (Ø w/o), and secondary emulsification (Ø w/o/w), manufacturing procedures, etc., from the first to the last step. Study of various parameters ultimately culminated in a marketable stable product rhat is expected to keep its physical stability over a period of 12 to 18 months, which will cover the usual shelf-life of a pharmaceutical preparation. Evaluation of this system showed a gradual and consistent drug release from the delivery system by a modified dialysis method through Visking selective permeable tubing.