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Abstract
Influence of surfactants over the dissolution of mequitazine was investigated by studying the dissolution of mequitazine (a poorly water-soluble drug) in different binary media prepared by adding different amounts of surfactants (Brij 35, Tween 20 or sodium lauryl sulfate (SLS)) into 1 liter of water. An improvement in drug dissolution rate was observed from all of the binary dissolution media, except those containing lower amounts of sodium lauryl sulfate. At lower concentrations, SLS acts as a true salt, and a competition is produced between drug and SLS for water molecules. Due to this saline effect, a decline in drug dissolution was observed from binary media with lower concentration of SLS