Frequent Allelic Loss of Dkk-1 Locus (10q11.2) is Related with Low Distant Metastasis and Better Prognosis in Head and Neck Squamous Cell Carcinomas

Naoki KataseDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan

Mehmet GunduzDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan

Levent Bekir BederDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan

Esra GunduzDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan

Mahmoud Al Sheikh AliDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan

Ryo TamamuraDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan

Kursat Oguz YaykasliDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan

Noboru YamanakaDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan

Kenji ShimizuDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan

Hitoshi NagatsukaDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan

show all

ABSTRACT

Head and neck squamous cell carcinoma (HNSCC) is a frequently occurring cancer worldwide. Dickkopf (Dkk)-1 gene is suggested to function as tumor suppressor gene (TSG) in several kinds of malignancies. In this study, we performed loss of heterozygosity (LOH) analysis of Dkk-1 and examined the correlation between LOH status and clinicopathological parameters for the first time. A pretty high LOH ratio (50%) was detected. Interestingly, in the cases with Dkk-1 retention group showed less distant metastasis and a tendency of longer disease free survival. These results indicate that Dkk-1 can play a role in HNSCC carcinogenesis and it may also be related to distant metastasis.

Keywords: :

ACKNOWLEDGMENT

This work was partially supported by grants-in-aid for scientific researches from the Ministry of Education, Culture, Sports, Science and Technology [19592109 (to H.N.), 20791337 (to R.T.)], Seed Innovation Research from Japan Science and Technology Agency (to M.G.), from Sumitomo Trust Haraguchi Memorial Cancer Research Promotion (to M.G.) and Astrazeneca Research Grant (to M.G.).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Frequent Allelic Loss of Dkk-1 Locus (10q11.2) is Related with Low Distant Metastasis and Better Prognosis in Head and Neck Squamous Cell Carcinomas

Information for

Open access

Opportunities

Help and information

Frequent Allelic Loss of Dkk-1 Locus (10q11.2) is Related with Low Distant Metastasis and Better Prognosis in Head and Neck Squamous Cell Carcinomas

ABSTRACT

ACKNOWLEDGMENT

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature