A Study of Three Polymorphic Sites of ADA Gene in Colon Cancer

C. SpinaDepartment of Surgery, University of Rome Tor Vergata, Rome, Italy,

P. SaccucciDivision of Human Populations, Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, Rome, Italy

E. CozzoliDivision of Human Populations, Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, Rome, Italy

E. BottiniDivision of Human Populations, Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, Rome, Italy

F. Gloria-BottiniDivision of Human Populations, Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, Rome, Italy

Abstract

Adenosine inhibits the immune response in tumors. Adenosine deaminase (ADA) controls adenosine level and as ecto-enzyme acts as costimulatory molecule of adenosine receptors and/or CD26. We examined ADA₁, ADA₂, ADA₆ polymorphic sites of ADA gene in 109 subjects with colon cancer from Rome's population and in 246 blood donors as controls from the same population. In colon cancer ADA₁*2/ADA₂*1 haplotype is more represented, while ADA₁*2/ADA₂*2 is less represented than in controls. ADA₂*2/ADA₆*2 is less represented in patients than in controls. Polymorphic sites of ADA might influence cell-mediated anti-tumor immune responses controlling adenosine level and extraenzymatic protein functions.

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A Study of Three Polymorphic Sites of ADA Gene in Colon Cancer

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A Study of Three Polymorphic Sites of ADA Gene in Colon Cancer

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