Association Between NFKB1 -94ins/delATTG Promoter Polymorphism and Cancer Risk: A Meta-Analysis

Yan-Feng ZouDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China, Department of Pharmacy, he Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu, China, and Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

Feng-Lai YuanDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China, Department of Pharmacy, he Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu, China, and Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaCorrespondence[email protected]

Xiao-Liang FengDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China, Department of Pharmacy, he Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu, China, and Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

Jin-Hui TaoDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China, Department of Pharmacy, he Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu, China, and Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

Ning DingDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China, Department of Pharmacy, he Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu, China, and Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

Fa-Ming PanDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China, Department of Pharmacy, he Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu, China, and Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

Fang WangDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China, Department of Pharmacy, he Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu, China, and Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaCorrespondence[email protected]

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Abstract

The aim of our meta-analysis was to assess the association between NFKB1 -94ins/delATTG promoter polymorphism and cancer risk. Eleven studies that included data from 2,743 cases and 2,195 controls were identified. When all groups were pooled, we did not detect the association between NFKB1 -94ins/delATTG promoter polymorphism and cancer risk. In the subgroup analysis, we detected the association of NFKB1 -94ins/delATTG promoter polymorphism with cancer in Caucasian population. The association also was found in Asian population. This meta-analysis demonstrates the association of NFKB1 -94ins/delATTG promoter polymorphism with cancer in Caucasian and Asian populations, and this association is ethno-specific.

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ACKNOWLEDGMENTS

We thank all the people who provided the help for this study. We have got the kind help from Dr. Kathrin Riemann, Dr. Hermann Brenner, Dr. Goetz F. Lehnerdt, Dr. Bin Zhou, Dr. Lin Zhang, Dr. Kuo-Wei Chang, Dr. AJ Vangsted, and Dr. Xiao-Feng Sun. This work was supported by grants from the National Natural Science Foundation of China (30972530).

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Association Between NFKB1 -94ins/delATTG Promoter Polymorphism and Cancer Risk: A Meta-Analysis

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Association Between NFKB1 -94ins/delATTG Promoter Polymorphism and Cancer Risk: A Meta-Analysis

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