Abnormal Histone Acetylation and Methylation Levels in Esophageal Squamous Cell Carcinomas

Chen ChenDepartment of Cardiothoracic Surgery, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

Ming ZhaoDepartment of Cardiothoracic Surgery, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

Ni YinDepartment of Cardiothoracic Surgery, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

Bin HeDepartment of Cardiothoracic Surgery, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

Baoxiang WangDepartment of Cardiothoracic Surgery, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

Yunchang YuanDepartment of Cardiothoracic Surgery, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

Fenglei YuDepartment of Cardiothoracic Surgery, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

Jianguo HuDepartment of Cardiothoracic Surgery, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

Bangliang YinDepartment of Cardiothoracic Surgery, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaCorrespondence[email protected]

Qianjin LuDepartment of Cardiothoracic Surgery, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaCorrespondence[email protected]

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Abstract

To investigate whether alterations in histone modifications occur in esophageal squamous cell carcinoma (ESCC), we measured histone H3/ H4 acetylation and H3K4/H3K27 methylation levels, as well as the expression of chromatin modifier genes in tumor and healthy esophageal tissue from ESCC patients. We found evidence of global H3 and H4 hypoacetylation, H3K4 and H3K27 hypermethylation in ESCC tissue. Both H3 hypoacetylation and H3K27 hypermethylation correlated with the severity and histological differentiation of the tumor, and H3K4 hypermethylation also correlated with tumor differentiation. Our results suggest that aberrant histone modifications may play an important role in the development and progression of ESCC.

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ACKNOWLEDGMENT

This study was supported by the National Natural Science Foundation of China (No 81000905/H1603) and The Free Exploration Program of Central South University (No. 201012200281).

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Abnormal Histone Acetylation and Methylation Levels in Esophageal Squamous Cell Carcinomas

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Abnormal Histone Acetylation and Methylation Levels in Esophageal Squamous Cell Carcinomas

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