Risk Estimation for a Malignant Transformation of Oral Lesions by S100A7 and Doc-1 Gene Expression

Abstract

The objective of this study was the correlation of Doc-1- and S100A7-gene expression in common oral lesions with their cancerous-transformation risk. Biopsies (n = 15 each) of healthy gingiva, irritation fibromas, leukoplakias and Oral squamous cell carcinoma (OSCCs) were obtained, and after RNA-extraction, transcripts of Doc-1 and S100A7 were quantified by RT-PCR. In comparison with the healthy gingiva, the expression of Doc-1 was decreased, whereas the expression of S100A7 was upregulated in all lesions. As the extent of Doc-1-inactivation and S100A7-overexpression is correlated with their biological behavior, the combined investigation of both genes could be a promising marker in intraoral lesions to estimate the risk for their malignant transformation.

Keywords: :

• Intraoral squamous cell carcinoma
• Doc-1
• S100A7
• Cancer

ACKNOWLEDGMENT

This study was supported by the BONFOR research foundation of the Medical Faculty of the University of Bonn. S. Jepsen (TP2), JP. Allam (TP1), and N. Novak (TP1) were supported by the German Research Foundation (CRU 208).