Polymorphisms in Interleukin-6-6331 Influences the Susceptibility of a Chinese Population to Gastric Cancer

Jun YuInstitute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China,Correspondence[email protected]

Yanhong Jia

Kin Fai CheungInstitute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China,

Zhirong ZengDepartment of Gastroenterology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China,

Linwei TianStanley Ho Center for Emerging Infectious Disease, The Chinese University of Hong Kong, Hong Kong, China

Shiyan WangInstitute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China,

Pinjin HuDepartment of Gastroenterology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China,

Joseph J. Y. SungInstitute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China,

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Abstract

We investigated the association of Interleukin (IL)-6-6331 polymorphisms with susceptibility to gastric cancer in 375 patients with gastric cancer and 386 age- and gender-matched healthy controls. After adjustment for the potential confounding effects of gender and age, IL-6-6331TC genotype was associated with a decreased risk of gastric cancer compared with the CC genotype. Further stratification analyses indicated that the protective effect of TC genotype was also observed in poorly differentiated gastric cancer, noncardia gastric cancer, and intestinal-type gastric cancer, respectively. These results suggest that the IL-6-6331 polymorphism is involved in susceptibility to developing gastric cancer.

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ACKNOWLEDGMENTS

This study was supported by the Council Competitive Earmarked Research Grant CUHK (473008), CUHK Group Research Scheme (3110043), and National Basic Research Program of China (973 Program, 2010CB529305).

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Polymorphisms in Interleukin-6-6331 Influences the Susceptibility of a Chinese Population to Gastric Cancer

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Polymorphisms in Interleukin-6-6331 Influences the Susceptibility of a Chinese Population to Gastric Cancer

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