Analysis of Matrix Metalloproteinase-1 Gene Polymorphisms and Expression in Benign and Malignant Breast Tumors

Abstract

A guanine insertion polymorphism in matrix metalloproteinase-1 promoter (MMP-1 2G) is linked to early onset and aggressiveness in cancer. We determined the role of MMP-1 2G on MMP-1 expression and breast cancer severity in patients with breast diseases. We observed no significant difference in genotype distribution among different disease groups. However, MMP-1 expression was significantly higher in atypical ductal hyperplasia than in benign breast disease and in invasive breast cancer compared to in situ breast cancer. MMP-1 2G insertion polymorphism in the invasive group also correlated significantly with the expression of MMP-1 and breast cancer prognostic markers HER2 and P53.

Keywords: :

• Breast cancers
• Detection/diagnosis
• Cancer biomarkers

ACKNOWLEDGMENT

This research was supported by a grant from the United States Department of Defense (Military Molecular Medicine Initiative MDA W81XWHH-05-2-0075, Protocol 01-20006), and by NIH-AR-26599 and NIH-CA-77267 to CB. The opinion and assertions contained herein are the private views of the authors and are not to be construed as official or as representing the views of the Department of the Army or the Department of Defense.