Carnitine Administration Reduces Cytokine Levels, Improves Food Intake, and Ameliorates Body Composition in Tumor-Bearing Rats

Alessandro LavianoDepartment of Clinical Medicine, Sapienza University of Rome, Rome, Italy,Correspondence[email protected]

Alessio Molfino

Marilia SeelaenderCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, São Pauloe, Brazil,

Teresa FrascariaDepartment of Clinical Medicine, Sapienza University of Rome, Rome, Italy,

Giuseppe Bertiniand Struttura Semplice Dipartimentale Stabilimento Allevatore Fornitore Utilizzatore, Istituti Fisioterapici Ospedalieri (SSD SAFU, IFO), Rome, Italy

Cesarina RamacciniDepartment of Clinical Medicine, Sapienza University of Rome, Rome, Italy,

Maria Rosa BolleaClinical Nutrition Service, Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy,

Gennaro Citroand Struttura Semplice Dipartimentale Stabilimento Allevatore Fornitore Utilizzatore, Istituti Fisioterapici Ospedalieri (SSD SAFU, IFO), Rome, Italy

Filippo Rossi FanelliDepartment of Clinical Medicine, Sapienza University of Rome, Rome, Italy,

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Abstract

Increased cytokine expression contributes to the pathogenesis of cancer anorexia–cachexia syndrome. Carnitine may reduce inflammation in chronic diseases. We tested the effects of L-propionylcarnitine (PC group) or saline (C group) on food intake (FI), body composition, and inflammatory status of MCA-sarcoma-bearing rats. On tumor appearance, rats were randomly assigned to daily i.p. injection of L-propionylcarnitine (250 mg/kgBW/d; n = 8) or saline (equal volume; n = 8). FI and fat-free mass wasting improved in PC rats only (p < .01 vs. controls). Cytokines’ levels decreased in PC rats vs. controls (p < .02). Results suggest that carnitine may ameliorate cancer anorexia–cachexia, via reduction of the inflammatory status.

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Carnitine Administration Reduces Cytokine Levels, Improves Food Intake, and Ameliorates Body Composition in Tumor-Bearing Rats

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Carnitine Administration Reduces Cytokine Levels, Improves Food Intake, and Ameliorates Body Composition in Tumor-Bearing Rats

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