Genetic Polymorphisms of UGT1A7 and Cancer Risk: Evidence From 21 Case–Control Studies

Pei-Hua LuDepartment of Surgery, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, Jiangsu Province, China,

Min-Bin ChenDepartment of Medical Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China,

Xiao-Yang WuDepartment of Surgical Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China,

Jin-Hua GuDepartment of Medical Laboratory Center, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China,

Yuan LiuThe Affiliated Eye Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China,

Rong-min GuDepartment of Surgery, Nanjing Medical University Affiliated Cancer Hospital of Jiangsu Province, Nanjing, Jiangsu Province, ChinaCorrespondence[email protected]

Abstract

The aim of our meta-analysis was to assess the association between UGT1A7 polymorphisms and cancer risk. Case–control studies containing available polymorphic alleles (UGT1A7*1,*2,*3, and*4) and genotypes categorized according to enzymatic activity (High, Intermediate, and Low) were chosen to assess this association. Twenty-one case–control studies were identified. Meta-analysis indicated that UGT1A7 had a significant effect on cancer risk. In subgroup analysis, a significantly increased risk was associated with East Asians, hepatocellular cancer, and colorectal cancer. This meta-analysis suggested that there is a cancer risk associated with UGT1A7*3, Intermediate, and Low activity UGT1A7 genotypes, which is most evident in Asian individuals.

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