Views

CrossRef citations to date

Altmetric

PRECLINICAL

Suppression of Epidermal Growth Factor Receptor (EGFR) Expression by Small Hairpin RNA Inhibits the Growth of Human Nonsmall Cell Lung Cancers Bearing Wild-type and Mutant EGFR

Shuang ZhangState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Hongwei TianState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Qingyuan JiangSichuan Provincial Hospital for Women and Children Chengdu, China,

Li LiDepartment of Pathology West China Hospital, Sichuan University, Chengdu, China,

Yu DingState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Lei DaiState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Yu XiangState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Guobo ShenState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Lin ChengState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Qiaorong HuangState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Yalin LiuState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Xiaomei ZhangState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Yongping MaState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Na ZhangState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Shengyong LiuState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Wei WangState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Lixia DaiState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Yiming LiState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Xia ZhaoDepartment of Gynecology and Obstetrics West China Second Hospital, Sichuan University, Chengdu, China

Yuquan WeiState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,

Hongxin DengState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University, Chengdu, China,Correspondence[email protected]

show all

Abstract

In the present study, we have used plasmid-based RNA interference (RNAi) strategy to downregulate the expression of epidermal growth factor receptor (EGFR) in EGFR wild-type (H292) and mutant (H1975) lung tumor models. The targeted knockdown of EGFR by small hairpin RNA not only inhibited growth of H292 xenograft but also inhibited H1975 lung cancer cell and xenograft, which bore L858R/T790M EGFR and was resistant to EGFR tyrosine kinase inhibitors. These data demonstrated that small hairpin RNA was an effective therapy against mutant EGFR-expressing cancer cells and thus considered to be a promising strategy in the treatment of lung cancers.

Keywords: :

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Suppression of Epidermal Growth Factor Receptor (EGFR) Expression by Small Hairpin RNA Inhibits the Growth of Human Nonsmall Cell Lung Cancers Bearing Wild-type and Mutant EGFR

Information for

Open access

Opportunities

Help and information

Suppression of Epidermal Growth Factor Receptor (EGFR) Expression by Small Hairpin RNA Inhibits the Growth of Human Nonsmall Cell Lung Cancers Bearing Wild-type and Mutant EGFR

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature