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Abstract
The significance of SOX2 in nasopharyngeal carcinoma (NPC), a tumor associated with Epstein–Barr virus (EBV), remains unclear. Here, we reported that, in the univariate analysis, SOX2 expression was correlated with a poorer distant metastasis-free survival (DMFS). The EBV-VCA/IgA titers in patients with NPC were also associated with a poorer overall survival (OS). Patients with NPC, who had both strong staining of SOX2 and high titers of EBV-VCA/IgA, had the poorest prognoses. Therefore, SOX2 or the combination of the SOX2 expression level and EBV-VCA/IgA titers could be valuable to predict distant metastasis or the prognosis of NPC.
ACKNOWLEDGMENTS
We thank members of the laboratory for their helpful comments on the manuscript. This work was supported by a key grant from NSFC (30930045), China's 973 Project (2010CB912201) (To T. K.), China's 863 Program (2006AA02A404), and the National Natural Science Foundation of China (u0732005) (To Y-X. Z).