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Abstract
rs2352028 in GPC5 has been reported to be associated with the risk of lung cancer in never-smokers. We performed a replication study in 1,045 lung cancer patients and 1,094 controls of Han Chinese origin. We found no association between rs2352028 and lung cancer/adenocarcinoma in never-smokers, but a p value of .04 (under the recessive model) was obtained between this SNP and overall lung cancer/adenocarcinoma. Our data and a recent meta-analysis suspected the possibility of rs2352028 being a risk variant of lung cancer risk in never-smokers. Our findings suggested that rs2352028 might confer a slight risk to lung cancer/adenocarcinoma.
ACKNOWLEDGMENTS
We warmly thank all the participants for their cooperation in this study and gratefully acknowledge all the physicians and nurses who assisted in studying the patients. This work was supported by 973 Program (2011CB504001, 2010CB529600, 2007CB947300, and 2006CB910601), the 863 Program (2006AA02A407 and 2009AA022701), the Shanghai Municipal Commission of Science and Technology Program (09DJ1400601), the National Key Project for Investigational New Drug (2008ZX09312–003), and the National Natural Science Foundation of China.