Analysis of Tie2-Expressing Monocytes (TEM) in Patients With Colorectal Cancer

Valentin GoedeDepartment of Internal Medicine I, University Hospital Cologne, Center of Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany,

Oliver CoutelleDepartment of Internal Medicine I, University Hospital Cologne, Center of Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany,

Alexander Shimabukuro-VornhagenDepartment of Internal Medicine I, University Hospital Cologne, Center of Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany,

Udo HoltickDepartment of Internal Medicine I, University Hospital Cologne, Center of Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany,

Janina NeuneierDepartment of Internal Medicine I, University Hospital Cologne, Center of Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany,

Thomas C. KoslowskyDepartment of Surgery, St. Elisabeth Hospital, Cologne, Germany

Martin R. WeihrauchDepartment of Internal Medicine I, University Hospital Cologne, Center of Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany,

Michael von Bergwelt-BaildonDepartment of Internal Medicine I, University Hospital Cologne, Center of Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany,

Ulrich T. HackerDepartment of Internal Medicine I, University Hospital Cologne, Center of Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany,Correspondence[email protected]

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Abstract

Tie2-expressing monocytes (TEM) promote tumor angiogenesis and growth in experimental cancer models. The role of TEM in cancer patients is unknown. We studied TEM in healthy volunteers and colorectal cancer (CRC) patients. Although TEM were detectable in the blood and tumor lesions of CRC patients, their frequency and functional phenotype showed no correlation with levels of angiopoietin-2 or vascular endothelial growth factor, microvessel density, tumor markers, tumor stage, or outcome of antiangiogenic therapy. These unexpected findings are at odds with murine tumor models and question the diagnostic or therapeutic value of TEM in human cancer.

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Analysis of Tie2-Expressing Monocytes (TEM) in Patients With Colorectal Cancer

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Analysis of Tie2-Expressing Monocytes (TEM) in Patients With Colorectal Cancer

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