Global Histone H3K27 Methylation Levels are Different in Localized and Metastatic Prostate Cancer

Jörg EllingerKlinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn, Bonn, Germany,Correspondence[email protected]

Philip KahlInstitut für Pathologie der Universität zu Köln, Cologne, Germany,

Johannes von der GathenKlinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn, Bonn, Germany,

Lukas C. HeukampInstitut für Pathologie der Universität zu Köln, Cologne, Germany,

Ines GütgemannInstitut für Pathologie, Universitätsklinikum Bonn, Bonn, Germany,

Bernhard WalterUrologische Universitätsklinik, Universitätsklinikum Erlangen, Erlangen, Germany,

Ferdinand HofstädterInstitut für Pathologie, Universitätsklinik Regensburg, Regensburg, Germany,

Patrick J. BastianUrologische Klinik und Poliklinik, Universitätsklinikum Großhadern, Munich, Germany

Alexander von RueckerInstitut für Pathologie, Universitätsklinikum Bonn, Bonn, Germany,

Stefan C. MüllerKlinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn, Bonn, Germany,

Sebastian RogenhoferKlinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn, Bonn, Germany,

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Abstract

Global histone modification patterns have been shown to be a predictive factor of recurrence in various cancers. We analyzed global histone-3-lysine-27 (H3K27) methylation in prostate cancer (PCA) tissues. H3K27 mono-, di-, and tri-methylation patterns were different in nonmalignant prostate tissue, localized PCA, metastatic PCA, and castration-resistant PCA. H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis.

Keywords: :

ACKNOWLEDGMENT

We thank Doris Schmidt for technical assistance.

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Global Histone H3K27 Methylation Levels are Different in Localized and Metastatic Prostate Cancer

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Global Histone H3K27 Methylation Levels are Different in Localized and Metastatic Prostate Cancer

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