Arsenic Trioxide Increases the Sensitivity of 786–0 Renal Carcinoma Cells to Radiotherapy

Yu SuDepartments of Urinary Surgery, Clinical Laboratory, and Radiotherapy, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China, Department of Urinary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China

XiaoMin WangDepartments of Urinary Surgery, Clinical Laboratory, and Radiotherapy, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China, Department of Urinary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, ChinaCorrespondence[email protected] [email protected]

WanHai XuDepartments of Urinary Surgery, Clinical Laboratory, and Radiotherapy, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China, Department of Urinary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China

Li XueDepartments of Urinary Surgery, Clinical Laboratory, and Radiotherapy, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China, Department of Urinary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China

ChunBo HeDepartments of Urinary Surgery, Clinical Laboratory, and Radiotherapy, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China, Department of Urinary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China

DeJun YangDepartments of Urinary Surgery, Clinical Laboratory, and Radiotherapy, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China, Department of Urinary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China

RuiHua AnDepartments of Urinary Surgery, Clinical Laboratory, and Radiotherapy, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China, Department of Urinary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, ChinaCorrespondence[email protected] [email protected]

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Abstract

We evaluated the combined effect of As₂O₃ and ionizing radiation on cultured renal carcinoma cells. The cells receiving both As₂O₃ and radiotherapy had more DNA damage, more apoptosis, more reactive oxygen species produced, more cells in G₂/M phase, and a lower mitochondrial membrane potential than cells treated with As₂O₃ only or with radiotherapy only (for all comparisons, p < .05). Renal carcinoma cells can be sensitized to ionizing radiation with As₂O₃, and combining As₂O₃ and radiation had larger effects than As₂O₃ only or radiation only.

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ACKNOWLEDGMENTS

This work was supported by the Fourth Affiliated Hospital of Harbin Medical University. I would like to thank my advisor for reading and carefully reviewing this manuscript.

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Arsenic Trioxide Increases the Sensitivity of 786–0 Renal Carcinoma Cells to Radiotherapy

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Arsenic Trioxide Increases the Sensitivity of 786–0 Renal Carcinoma Cells to Radiotherapy

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