ERCC1 Polymorphisms and Risk of Adult Glioma in a Chinese Population: A Hospital-Based Case-Control Study

Abstract

To examine the associations of two polymorphisms in excision repair cross-complementing rodent repair deficiency complementation group 1 (ERCC1) gene, C8092A (rs3212986) and T19007C (rs11615), with the risk of adult glioma, we performed a hospital-based case-control study with 257 new cases of glioma and 278 controls in Wenzhou, China. Results showed that polymorphisms C8092A and T19007C in ERCC1 gene were not associated with the risk of glioma in a Chinese population. Further studies in Chinese populations with larger sample sizes are still warranted.

Keywords: :

• Glioma
• DNA repair
• ERCC1
• Polymorphism

ACKNOWLEDGMENT

We thank colleagues at the Second Affiliated Hospital of Wenzhou Medical College for their help and support in the fieldwork of this study.