Differential Expression of Kv1.3 and Kv1.5 Voltage-Dependent K⁺ Channels in Human Skeletal Muscle Sarcomas

Abstract

Because Kv1.3 and Kv1.5 K⁺ channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adult muscle and low in ERMS, whereas it was notable in ARMS and embryonic samples. Kv1.3 expression showed no major differences between RMS and healthy samples. We found a correlation of Kv1.3 and Kv1.5 expression with the tumor malignancy.

Keywords: :

• Potassium channels
• Skeletal muscle
• Cancer
• Alveolar rhabdomyosarcomas
• Embryonal rhabdomyosarcomas

ACKNOWLEDGMENTS

Antonio Felipe was supported by the Ministerio de Ciencia e Innovación (MICINN), Spain (BFU2008-00431, BFU2011-23268, and CSD2008-00005). Joanna Bielanska holds a fellowship from the MICINN. The editorial assistance of the American Journal Experts is also acknowledged. Joan Carles Ferreres and Antonio Felipe contributed equally to this work.