Tumor Cell Expression of Heat Shock Protein (HSP) 72 is Influenced by HSP72 [HSPA1B A(1267)G] Polymorphism and Predicts Survival in Small Cell Lung Cancer (SCLC) Patients

Klara SzondyDepartment of Pulmonology, Semmelweis University, Budapest, Hungary,

Krisztina Rusai1st Department of Pediatrics, and Research Laboratory of the Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary

Attila J. Szabó1st Department of Pediatrics, and Research Laboratory of the Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary

Andrea NagyDepartment of Pulmonology, Semmelweis University, Budapest, Hungary,

Krisztina Gal

Andrea Fekete1st Department of Pediatrics, and Research Laboratory of the Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary

Zsuzsanna KovatsDepartment of Pulmonology, Semmelweis University, Budapest, Hungary,

Gyorgy LosonczyDepartment of Pulmonology, Semmelweis University, Budapest, Hungary,

József LukacsovitsDepartment of Pulmonology, Semmelweis University, Budapest, Hungary,

Veronika MüllerDepartment of Pulmonology, Semmelweis University, Budapest, Hungary,Correspondence[email protected]

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Abstract

The inducible heat shock protein (HSP)72 plays a central role in antitumor immunomodulation. HSP72 expression was assessed on tumor samples of 43 patients with advanced and metastatic small cell lung cancer (SCLC) by immunohistochemistry and HSP72 [HSPA1B A(1267)G] polymorphism was determined. HSP72 expression of SCLC cells was significantly decreased in GG as compared to cells of AA or AG genotype patients, and was associated with significantly shorter survival in GG patients as compared to carriers of the A allele. Decreased HSP72 expression of SCLC cells associated with HSP72 GG genotype is a negative prognostic factor for survival in SCLC patients.

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ACKNOWLEDGMENT

This work was supported by ETT, TAMOP-4.2.1.B-09/1/KMR, OTKA F042563, L83499, Semmelweis University and MTT grants. Veronika Müller, Attila Szabo, and Andrea Fekete were recipients of Bolyai Scholarship of the Hungarian Academy of Sciences. Technical assistance of Beryll Bornemisza and Mária Bernáth is highly appreciated.

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Tumor Cell Expression of Heat Shock Protein (HSP) 72 is Influenced by HSP72 [HSPA1B A(1267)G] Polymorphism and Predicts Survival in Small Cell Lung Cancer (SCLC) Patients

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Tumor Cell Expression of Heat Shock Protein (HSP) 72 is Influenced by HSP72 [HSPA1B A(1267)G] Polymorphism and Predicts Survival in Small Cell Lung Cancer (SCLC) Patients

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