Detection of MAGE-A Expression Predicts Malignant Transformation of Oral Leukoplakia

Jutta RiesDepartment of Oral and Maxillofacial Surgery, Erlangen University Hospital, Erlangen, Germany,Correspondence[email protected]

Abbas AgaimyInstitute of Pathology, Erlangen University Hospital, Erlangen, Germany,

Elefterios VairaktarisDepartment of Oral and Maxillofacial Surgery, University of Athens, Athens, Greece

Patricia GoreckiDepartment of Oral and Maxillofacial Surgery, Erlangen University Hospital, Erlangen, Germany,

Friedrich W. NeukamDepartment of Oral and Maxillofacial Surgery, Erlangen University Hospital, Erlangen, Germany,

Lei H. StraßburgDepartment of Oral and Maxillofacial Surgery, Erlangen University Hospital, Erlangen, Germany,

Emeka NkenkeDepartment of Oral and Maxillofacial Surgery, Erlangen University Hospital, Erlangen, Germany,

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Abstract

The study aimed at checking if MAGE-A expression in oral leukoplakia (OLP) lesions is related to malignant transformation. The 48 samples of OLP that transformed to oral squamous cell carcinoma (OSCC) (group 1) and 50 samples of OLP that did not transform to OSCC (group 2) were included in the study. The expression of MAGE-A was restricted to group 1. The correlation between malignant transformation and MAGE-A occurrence in OLP was statistically significant (p < .0001). Detection of MAGE-A may allow identifying OLP with a high risk of malignant transformation giving a view to a new approach to prevention of oral cancer.

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Detection of MAGE-A Expression Predicts Malignant Transformation of Oral Leukoplakia

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Detection of MAGE-A Expression Predicts Malignant Transformation of Oral Leukoplakia

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