Immune Protection Function of Multipotent Mesenchymal Stromal Cells: Role of Transforming Growth Factor-β1

Zhi-Gang ZhaoDepartment of Hematology and Oncology, the Oncology Hospital of Tianjin Medical University, Tianjin, P.R. China,Correspondence[email protected]

Zeng CaoInstitute of Hematology and Blood Diseases Hospital, State Key Lab of Experimental Method of Hematology, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin, P.R. China,

Wen XuDepartment of Hematology and Oncology, the Oncology Hospital of Tianjin Medical University, Tianjin, P.R. China,

Li SunDepartment of Hematology, Institute of Hematology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, P.R. China

Yong YouDepartment of Hematology, Institute of Hematology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, P.R. China

Fang LiDepartment of Hematology and Oncology, the Oncology Hospital of Tianjin Medical University, Tianjin, P.R. China,

Qiu-Bai LiDepartment of Hematology, Institute of Hematology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, P.R. China

Ping ZouDepartment of Hematology, Institute of Hematology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, P.R. China

show all

Abstract

The immunosuppressive functions of multipotent mesenchymal stromal cells (MSCs) may give cancer cells a survival advantage. This study tests the hypothesis that MSCs protect leukemia cells from immune clearance. Our results demonstrate that MSCs are capable of inhibiting peripheral blood mononuclear cells (PBMNCs) proliferation and their migration toward leukemic cells by the reduction of CCL5 and CXCL12. In addition, we find that MSCs can inhibit the cytolytic functions of NK-cells and CTLs. TGF-β1 secreted by MSCs is responsible for impaired CTLs and NK function by down-modulating surface NKG2D expression. These inhibitory functions of MSCs have negative effects on the CTLs or NK-mediated graft-versus-leukemia (GVL), particularly in the allogeneic hematopoietic stem cells transplantation setting.

Keywords: :

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Immune Protection Function of Multipotent Mesenchymal Stromal Cells: Role of Transforming Growth Factor-β1

Information for

Open access

Opportunities

Help and information

Immune Protection Function of Multipotent Mesenchymal Stromal Cells: Role of Transforming Growth Factor-β1

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature