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ORIGINAL ARTICLE

Elevated Serum IL-8 Is Associated with the Presence of Hepatocellular Carcinoma and Independently Predicts Survival

, , , &
Pages 689-697 | Published online: 16 Oct 2012
 

Abstract

Tumor immune responses have prognostic importance to hepatocellular carcinoma (HCC). Serum cytokines may differentiate HCC patients from cirrhotic patients or have prognostic significance. Serum IL-8 was elevated in 90 HCC patients compared to 180 cirrhotic controls, whereas IL-1β, IL-2, IL-4, IL-6, IL-7, IL-10, IL-12, IL-13, IL-15, IL-17, IL-21, and VEGF were similar. IL-8 predicted HCC presence with an area under the receiver–operator curve (ROC) of 0.68. HCC patients with highest IL-8 had worse survival. Multivariate analysis showed that high IL-8 (HR 2.15; 95%CI:1.21–3.74) and stage (HR 1.92; 95%CI:1.22–3.97) independently predicted mortality; while viral etiology was protective (HR 0.69; 95%CI:0.41–0.98). Therefore, HCC IL-8 mediated events may be worthy of future investigation.

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