The Complexity of Identifying Cancer Stem Cell Biomarkers

Zarine KhanBrain Tumour North West, Faculty of Science and Technology, University of Central Lancashire, Preston, UK

Amal ShervingtonBrain Tumour North West, Faculty of Science and Technology, University of Central Lancashire, Preston, UKCorrespondence[email protected]

Chinmay MunjeBrain Tumour North West, Faculty of Science and Technology, University of Central Lancashire, Preston, UK

Leroy ShervingtonBrain Tumour North West, Faculty of Science and Technology, University of Central Lancashire, Preston, UK

Abstract

The efficacy of glioma therapy can be considerably improved if it eliminates cancer stem cells (CSCs); however, to achieve this, CSCs markers are required. This study investigated the influence of micro-environmental changes on CSCs in hypoxic, serum deprived U87-MG and the corresponding control cells. Proteomic analysis produced a wide dataset, depicting the changes that occur at the proteomic level in the differentiated and undifferentiated U87-MG cell line. With the IPA analysis, HPRD and literature reviews, 11 proteins were proposed as potential differentiated biomarkers for CSCs namely Hsp90β1, vimentin, PGK1, GAPDH, EIF4e, TPI1, HspA8, HNRNPK, NAMPT, CCSNK2A1, and ANXA2.

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The Complexity of Identifying Cancer Stem Cell Biomarkers

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The Complexity of Identifying Cancer Stem Cell Biomarkers

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