Routine Histopathologic Characteristics Can Predict Oncotype DX^TM Recurrence Score in Subsets of Breast Cancer Patients

Abstract

This study assessed whether routine pathologic parameters could predict Oncotype DX^TM recurrence score (RS) in 72 breast cancers diagnosed from 2008–2012. Comparing patients with low RS (0–17) vs. intermediate RS (18–30) vs. high RS (>30), the mean Nottingham score increased (5.5 vs. 6.3 vs. 7.2, respectively, p = .001) and the mean PR Allred score decreased (6.7 vs. 4.9 vs. 3.3, respectively, p = .001). A high RS was least likely for low-grade tumors (0% had high RS, p = .005), and strong PR positivity (9% had high RS, p = .017). A low RS was least likely for cancers that were both high grade and PR weak/negative.

Keywords: :

• Breast cancers
• Oncotype DX
• PR expression