Upregulation of Human Mammaglobin Reduces Migration and Invasion of Breast Cancer Cells

Eun-Ha KohDepartments of Physiology, Laboratory Medicine, and Radiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, South Korea

Young-Woo ChoDepartments of Physiology, Laboratory Medicine, and Radiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, South Korea

Yun-Ja MunDepartments of Physiology, Laboratory Medicine, and Radiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, South Korea

Ji Hyeon RyuDepartments of Physiology, Laboratory Medicine, and Radiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, South Korea

Eun-Jin KimDepartments of Physiology, Laboratory Medicine, and Radiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, South Korea

Dae Seob ChoiDepartments of Physiology, Laboratory Medicine, and Radiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, South Korea

Kook-Young MaengDepartments of Physiology, Laboratory Medicine, and Radiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, South Korea

Jaehee HanDepartments of Physiology, Laboratory Medicine, and Radiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, South Korea

Dawon KangDepartments of Physiology, Laboratory Medicine, and Radiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, South KoreaCorrespondence[email protected]

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Abstract

Little is known about the biological role of human mammaglobin (hMAM) that is considered as a promising marker for breast cancer. Here, we investigated hMAM's role related to migration and invasion of human breast cancer cells (hBCC). Compared to normal cells, hBCC have high MAM mRNA expression levels. Of the hBCC tested, MAM mRNA expression levels were higher in noninvasive than in invasive cells. Overexpression of hMAM in breast cancer cells decreased migration and invasion, whereas knockdown of hMAM increased both. Taken together, these results suggest that metastasis of hBCC could be controlled by hMAM expression levels.

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ACKNOWLEDGMENTS

This work was supported by an NRF grant funded by the Korea government (2005-0049415 and 2010-0024258) and by biomedical research institute fund (GNUHBRIF-2013-0004) from the Gyeongsang National University Hospital (to Eun-Ha Koh).

Abbreviations: MAM, mammaglobin

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Upregulation of Human Mammaglobin Reduces Migration and Invasion of Breast Cancer Cells

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Upregulation of Human Mammaglobin Reduces Migration and Invasion of Breast Cancer Cells

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