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Cancer Investigation Volume 32, 2014 - Issue 4
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ORIGINAL ARTICLE

Presurgical Trial of Metformin in Overweight and Obese Patients with Newly Diagnosed Breast Cancer

Kevin KalinskyDepartment of Medicine, College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, Departments of Epidemiology and Biostatistics, Mailman School of Public Health, Department of Surgery, College of Physicians and Surgeons, Department of Medicine, Laboratory Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
,
Katherine D. CrewDepartment of Medicine, College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, Departments of Epidemiology and Biostatistics, Mailman School of Public Health, Department of Surgery, College of Physicians and Surgeons, Department of Medicine, Laboratory Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
,
Susan ReficeDepartment of Medicine, College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, Departments of Epidemiology and Biostatistics, Mailman School of Public Health, Department of Surgery, College of Physicians and Surgeons, Department of Medicine, Laboratory Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
,
Tong XiaoDepartment of Medicine, College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, Departments of Epidemiology and Biostatistics, Mailman School of Public Health, Department of Surgery, College of Physicians and Surgeons, Department of Medicine, Laboratory Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
,
Antai WangDepartment of Medicine, College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, Departments of Epidemiology and Biostatistics, Mailman School of Public Health, Department of Surgery, College of Physicians and Surgeons, Department of Medicine, Laboratory Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
,
Sheldon M. FeldmanDepartment of Medicine, College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, Departments of Epidemiology and Biostatistics, Mailman School of Public Health, Department of Surgery, College of Physicians and Surgeons, Department of Medicine, Laboratory Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
,
Bret TabackDepartment of Medicine, College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, Departments of Epidemiology and Biostatistics, Mailman School of Public Health, Department of Surgery, College of Physicians and Surgeons, Department of Medicine, Laboratory Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
,
Aqeel AhmadDepartment of Medicine, College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, Departments of Epidemiology and Biostatistics, Mailman School of Public Health, Department of Surgery, College of Physicians and Surgeons, Department of Medicine, Laboratory Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
,
Serge CremersDepartment of Medicine, College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, Departments of Epidemiology and Biostatistics, Mailman School of Public Health, Department of Surgery, College of Physicians and Surgeons, Department of Medicine, Laboratory Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
,
Hanina HibshooshDepartment of Medicine, College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, Departments of Epidemiology and Biostatistics, Mailman School of Public Health, Department of Surgery, College of Physicians and Surgeons, Department of Medicine, Laboratory Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
,
Matthew MaurerDepartment of Medicine, College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, Departments of Epidemiology and Biostatistics, Mailman School of Public Health, Department of Surgery, College of Physicians and Surgeons, Department of Medicine, Laboratory Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
&
Dawn L. HershmanDepartment of Medicine, College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, Departments of Epidemiology and Biostatistics, Mailman School of Public Health, Department of Surgery, College of Physicians and Surgeons, Department of Medicine, Laboratory Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USACorrespondence[email protected]
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Pages 150-157 | Received 22 Oct 2013, Accepted 28 Jan 2014, Published online: 07 Mar 2014
 
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Abstract

Introduction: We conducted a presurgical trial to assess the tissue-related effects of metformin in overweight/obese breast cancer (BC) patients. Methods: Metformin 1,500 mg daily was administered to 35 nondiabetics with stage 0–III BC, body mass index (BMI) ≥ 25 kg/m2. The primary endpoint was tumor proliferation change (i.e., ki-67). Tumor proliferation change was compared to untreated historical controls, matched by age, BMI, and stage. Results: There was no reduction in ln(ki-67) after metformin (p = .98) or compared to controls (p = .47). There was a significant reduction in BMI, cholesterol, and leptin. Conclusion: Despite no proliferation changes, we observed reductions in other relevant biomarkers.

Table S1 Changes in Absolute Tumor Proliferation (ki-67) in Evaluable Metformin-Treated Patients and Matched Historical Controls

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