Biological Effects of ¹²⁵I Seeds Radiation on A549 Lung Cancer Cells: G2/M Arrest and Enhanced Cell Death

Ang QuDepartment of Radiation Oncology, Peking University Third Hospital, Beijing, P.R. China,

Hao WangDepartment of Radiation Oncology, Peking University Third Hospital, Beijing, P.R. China,

Jinna LiDepartment of Radiation Oncology, Peking University Third Hospital, Beijing, P.R. China,

Junjie WangDepartment of Radiation Oncology, Peking University Third Hospital, Beijing, P.R. China,Correspondence[email protected]

Jingjia LiuDepartment of Radiation Oncology, Peking University Third Hospital, Beijing, P.R. China,

Yuzhu HouTransplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, P.R. China

Li HuangDepartment of Radiation Oncology, Peking University Third Hospital, Beijing, P.R. China,

Yong ZhaoTransplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, P.R. China

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Abstract

External beam radiation (EBRT) and ¹²⁵I seeds continuous low dose rate radiation (CLDR) were used to treat patients with lung cancer. We herein investigated the biological effects of EBRT and CLDR on lung cancer cells. A549 human lung cancer cell line was thus exposed to different doses of EBRT and CLDR. CLDR was more efficient to inhibit cell growth than EBRT. CLDR induced increased DNA damage as evidenced by long-lasting p-H2AX activity. The enhanced inhibitory effects of CLDR on lung cancer cell growth may be, at least in part, due to the increased Bax/Bcl2 ratio and cyclin B1-mediated G2/M arrest.

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Biological Effects of ¹²⁵I Seeds Radiation on A549 Lung Cancer Cells: G2/M Arrest and Enhanced Cell Death