PLCE1 Suppresses p53 Expression in Esophageal Cancer Cells

Abstract

The apoptotic mechanism dysfunction plays a critical role in cancer cell growth and escaping from cancer therapies; the underlying mechanisms are to be further elucidated. This study aims to investigate the role of phospholipase C epsilon 1 (PLCE1) in modulating the apoptosis mechanism in esophageal cancer (Eca) cells. The results showed that Eca cell lines, OE33 and CP-C cells expressed high levels of PLCE1. Knockdown of PLCE1 markedly increased 9.26 folds of the expression of p53 and 13.8 folds of the frequency of apoptotic CP-C cells via modulating the p53 promoter methylation.

Keywords: :

• Esophageal cancer
• Phospholipase C epsilon 1
• P53
• Apoptosis
• Signal transducer and activator of transcription 3

Notice of Correction

Changes have been made to this article since its original online publication date of 25 April 2014.