B7-H3 was Highly Expressed in Human Primary Hepatocellular Carcinoma and Promoted Tumor Progression

Guoyan WangDepartment of Clinical Laboratory, the Yantai Affiliated Hospital of Binzhou Medical University, Yantai, P.R. China,

Tongshen LiuDepartment of Immunology, Binzhou Medical University, Yantai, P.R. China,

Guohua YuDepartment of Pathology, Yuhuangding Hospital, Yantai, P.R. China,

Guangbo ZhangClinical Immunology Laboratory, the First Affiliated Hospital of Suzhou University, Suzhou, P.R. China

Xiying LuanDepartment of Immunology, Binzhou Medical University, Yantai, P.R. China,Correspondence[email protected]

Abstract

B7-H3 has been detected in different cancers and correlated to tumor progression and outcome in cancer patients. In this study, we investigated the expression of B7-H3 in tissues and cells of primary hepatocellular carcinoma (PHC) patients. The research showed that B7-H3 is aberrantly expressed in PHC tissues and cells, and its high expression on HepG2 cells significantly promotes cell proliferation, adhesion, migration, and invasion capacity; moreover, it inhibits the proliferation of CD8⁺ T cells. Thus, B7-H3 may have a critical role in PHC and it may enhance tumor escape from the immune surveillance of CD8⁺ T cells.

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B7-H3 was Highly Expressed in Human Primary Hepatocellular Carcinoma and Promoted Tumor Progression

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B7-H3 was Highly Expressed in Human Primary Hepatocellular Carcinoma and Promoted Tumor Progression

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