Differential Expression of miR-125a-5p and let-7e Predicts the Progression and Prognosis of Non-Small Cell Lung Cancer

Wang-Yu ZhuDepartment of The Joint Laboratory of Immunogenomics, Zhoushan Hospital-BIG/CAS, Zhoushan Hospital, Zhoushan, Zhejiang, China,

Bin LuoDepartment of The Joint Laboratory of Immunogenomics, Zhoushan Hospital-BIG/CAS, Zhoushan Hospital, Zhoushan, Zhejiang, China,

Ji-yuan AnInstitute of Digital Agriculture, Zhejiang Academy of Agricultural sciences, Hangzhou, Zhejiang, China

Jian-ying HeDepartment of The Joint Laboratory of Immunogenomics, Zhoushan Hospital-BIG/CAS, Zhoushan Hospital, Zhoushan, Zhejiang, China,

Dong-dong ChenDepartment of The Joint Laboratory of Immunogenomics, Zhoushan Hospital-BIG/CAS, Zhoushan Hospital, Zhoushan, Zhejiang, China,

Li-Yun XuDepartment of The Joint Laboratory of Immunogenomics, Zhoushan Hospital-BIG/CAS, Zhoushan Hospital, Zhoushan, Zhejiang, China,

Yan-Yan HuangDepartment of The Joint Laboratory of Immunogenomics, Zhoushan Hospital-BIG/CAS, Zhoushan Hospital, Zhoushan, Zhejiang, China,

Xiao-Guang LiuDepartment of The Joint Laboratory of Immunogenomics, Zhoushan Hospital-BIG/CAS, Zhoushan Hospital, Zhoushan, Zhejiang, China,

Han-bo LeDepartment of Cardio-Thoracic Surgery, Zhoushan Hospital, Zhoushan, Zhejiang, China,

Yong-Kui ZhangDepartment of Cardio-Thoracic Surgery, Zhoushan Hospital, Zhoushan, Zhejiang, China,Correspondence[email protected] [email protected] [email protected]

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Abstract

Aberrant expression of various microRNAs (miRNA) has shown diagnostic and prognostic significance in non-small cell lung cancer (NSCLC). qRT-PCR analysis confirmed altered expression of miR-125a-5p, let-7e, miR-30a, miR-30e and miR-30e-3p in 70 paired tissue and serum samples from NSCLC patients. The reduced expression of miR-125a-5p, let-7e and miR-30e was strongly associated with NSCLC dedifferentiation. The lost expression of miR-125a-5p and let-7e was associated with shorter overall survival and let-7e was an independent prognostic factor for NSCLC patients. These five miRNA expressions should be further evaluated as biomarkers for the early detection and prognosis of NSCLC patients.

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Changes have been made to this article since its original online publication date of 19 June 2014.

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Differential Expression of miR-125a-5p and let-7e Predicts the Progression and Prognosis of Non-Small Cell Lung Cancer

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Differential Expression of miR-125a-5p and let-7e Predicts the Progression and Prognosis of Non-Small Cell Lung Cancer

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