Evaluation of Eight Plasma Proteins as Candidate Blood-Based Biomarkers for Malignant Gliomas

Ryan P. LangeThe Johns Hopkins University, School of Medicine, Departments of Pediatrics Emergency Medicine Neurosurgery, and Oncology, Baltimore, MD, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA

Allen EverettThe Johns Hopkins University, School of Medicine, Departments of Pediatrics Emergency Medicine Neurosurgery, and Oncology, Baltimore, MD, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA

Pratima DulloorThe Johns Hopkins University, School of Medicine, Departments of Pediatrics Emergency Medicine Neurosurgery, and Oncology, Baltimore, MD, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA

Frederick K. KorleyThe Johns Hopkins University, School of Medicine, Departments of Pediatrics Emergency Medicine Neurosurgery, and Oncology, Baltimore, MD, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA

Chetan BettegowdaThe Johns Hopkins University, School of Medicine, Departments of Pediatrics Emergency Medicine Neurosurgery, and Oncology, Baltimore, MD, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA

Cherie BlairThe Johns Hopkins University, School of Medicine, Departments of Pediatrics Emergency Medicine Neurosurgery, and Oncology, Baltimore, MD, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA

Stuart A. GrossmanThe Johns Hopkins University, School of Medicine, Departments of Pediatrics Emergency Medicine Neurosurgery, and Oncology, Baltimore, MD, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA

Matthias HoldhoffThe Johns Hopkins University, School of Medicine, Departments of Pediatrics Emergency Medicine Neurosurgery, and Oncology, Baltimore, MD, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USACorrespondence[email protected]

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Abstract

Eight brain-derived proteins were evaluated regarding their potential for further development as a blood-based biomarker for malignant gliomas. Plasma levels for glial fibrillary acidic protein, neurogranin, brain-derived neurotrophic factor, intracellular adhesion molecule 5, metallothionein-3, beta-synuclein, S100 and neuron specific enolase were tested in plasma of 23 patients with high-grade gliomas (WHO grade IV), 11 low-grade gliomas (WHO grade II), and 15 healthy subjects. Compared to the healthy controls, none of the proteins appeared to be specific for glioblastomas. However, the data are suggestive of higher protein levels in gliosarcomas (n = 2), which may deserve further exploration.

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Evaluation of Eight Plasma Proteins as Candidate Blood-Based Biomarkers for Malignant Gliomas

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Evaluation of Eight Plasma Proteins as Candidate Blood-Based Biomarkers for Malignant Gliomas

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