Glioma-Derived Thrombospondin-1 Modulates Cd14+ Cell Tolerogenic Properties

Yuan MaGraduate Management Team, Third Military Medical University, Chongqing, China;Department of Neurosurgery, Chengdu Military General Hospital, Chengdu, China

Bo QuDepartment of Orthopedics, Chengdu Military General Hospital, PLA, Chengdu, China

Xun XiaGraduate Management Team, Third Military Medical University, Chongqing, China;Department of Neurosurgery, Chengdu Military General Hospital, Chengdu, China

Libin YangDepartment of Neurosurgery, Chengdu Military General Hospital, Chengdu, China

Yongqin KuangDepartment of Neurosurgery, Chengdu Military General Hospital, Chengdu, China

Tao YangDepartment of Neurosurgery, Chengdu Military General Hospital, Chengdu, China

Jingmin ChengGraduate Management Team, Third Military Medical University, Chongqing, China;Department of Neurosurgery, Chengdu Military General Hospital, Chengdu, China

Haodong SunDepartment of Neurosurgery, Chengdu Military General Hospital, Chengdu, China

Kexia FanDepartment of Neurosurgery, Chengdu Military General Hospital, Chengdu, China

Jianwen GuDepartment of Neurosurgery, Chengdu Military General Hospital, Chengdu, ChinaCorrespondence[email protected]

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Abstract

Thrombospondin-1 (TSP1) plays a role in the immune tolerance, and is involved in the pathogenesis of glioma. This study aims to investigate the role of the glioma-derived TSP1 in the induction of the tumor immune tolerance. The results showed that the primary human glioma cells expressed high levels of TSP1. Glioma cells enhanced the expression of transforming growth factor (TGF)-β in CD4⁺ CD16⁻ naïve monocytes (Mos). The TGF-β⁺ Mos showed inhibitory effect on CD8⁺ T cell proliferation. We conclude that glioma cell-derived TSP1 facilitates the induction of TGF-β in Mos. The TSP1 may be a potential therapeutic target of glioma.

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Glioma-Derived Thrombospondin-1 Modulates Cd14+ Cell Tolerogenic Properties

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Glioma-Derived Thrombospondin-1 Modulates Cd14+ Cell Tolerogenic Properties

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