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ABSTRACT
This meta-analysis aims to evaluate chemotherapy with XELOX (capecitabine plus oxaliplatin) versus FOLFOX (fluorouracil plus oxaliplatin) as a treatment for metastatic colorectal cancer (mCRC) in terms of efficacy and safety.
Only randomized controlled trials (RCTs) comparing XELOX versus FOLFOX were included.
A total of 4,363 patients from eight RCTs were available for analysis. Pooled analysis revealed that there were no statistical differences between both arms in OS, and ORR. XELOX arm had a higher incidence of thrombocytopenia, hand-foot syndrome, and diarrhea, whereas neutropenia had a higher incidence in the FOLFOX group.
For mCRC, the effect of XELOX is similar to FOLFOX.
Declaration of interest
The authors report no conflicts of interest.