Response of Previously Irradiated Skin to Combinations of X Radiation, Hyperthermia, and cis-Diamminedichloroplatinum

Abstract

Mouse legs were irradiated to a dose of 30 Gy. After 50 days, when the acute reaction had regressed to a steady state, they were retreated with either various doses of x rays (15 to 30 Gy), hyperthermia, 45 min at 42.7°c, cis-DDP, or a combination of these agents. The maximum skin reactions and the skin reactions integrated over 50 days were determined. Statistical analysis of these data indicated the thermal enhancement ratio for the previously irradiated skin was approximately 1.20. The combination of x irradiation, hyperthermia, and cis-DDP treatments to the previously irradiated skin did not enhance the radiation damage beyond that produced by x irradiation and hyperthermia.