Vinblastine, Bleomycin, and cis-Platin as Salvage Therapy for MOPP Treated Patients with Hodgkin's Lymphoma

Abstract

Seven patients with active Hodgkin's lymphoma who had relapsed 4--39 months following six or more cycles of MOPP were treated with a combination of vinblastine-bleomycin-cis-platin (VBP). Six patients attained a partial response of 1--8 months duration. There were no complete responses. The projected maximum long-term disease-free survivorship with this salvage program is less than 16%. All observed patients had Grade II---III nausea and vomiting, and neutrophil nadir counts less than 700/mm³. Three patients had platelet counts ≤ 85,000/mm³. This program does not have significant potential as a salvage therapy for patients with Hodgkin's lymphoma relapsing after MOPP chemotherapy