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Original Article

Radiation-Induced Malignant Fibrous Histiocytoma: A Report of Five Cases Including Two Occurring Post Whole Brain Irradiation

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Pages 507-513 | Published online: 11 Jun 2009
 

Abstract

Five patients who were successfully treated with external radiation therapy for a variety of histologically unrelated tumors subsequently developed malignant fibrous histiocytoma (MFH) within the irradiated field. It is suggested that therapeutic irradiation was a causative factor in the development of these tumors with latent periods ranging between 3 and 17 years. A review of the pertinent literature is presented. It is apparent that postradiation MFH is being recognized with increasing frequency and at an earlier age than when it appears de novo.

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