Cancer-Associated Lactate Dehydrogenase is a Tyrosylphosphorylated Form of Human LDH-A, Skeletal Muscle Isoenzyme

Steven S.-L. Li Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709

Yu-Ching E. Pan Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709; Department of Protein Biochemistry, Hoffmann-La Roche, Inc., Nutley, New Jersey, 07110

Farida S. Sharief Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709

Mary Jo Evans Department of Biological Resources, Roswell Park Memorial Institute, Buffalo, New York, 14263

Ming-Fong Lin Department of Biochemistry, Louisiana State University Medical Center, New Orleans, Louisiana, 70112

Gail M. Clinton Department of Biochemistry, Louisiana State University Medical Center, New Orleans, Louisiana, 70112

J. John Holbrook Department of Biochemistry, University of Bristol Medical School, University Walk, Bristol, BS8 lTD, United Kingdom

show all

Abstract

Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human skeletal muscle isoenzyme, since the partial amino acid sequences of human liver LDH-K/A protein were found to be identical with the known primary structure of human LDH-A isoenzyme and the LDH-A isoenzymes from human placenta and bovine muscle were shown to be tyrosylphosphorylated. This tyrosylphosphorylated LDH-K/A protein was also found to be complexed with 21 kD, 30 kD, and 56 kD proteins.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Cancer-Associated Lactate Dehydrogenase is a Tyrosylphosphorylated Form of Human LDH-A, Skeletal Muscle Isoenzyme

Information for

Open access

Opportunities

Help and information

Cancer-Associated Lactate Dehydrogenase is a Tyrosylphosphorylated Form of Human LDH-A, Skeletal Muscle Isoenzyme

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature