Tumor Growth-Promoting Effect of Immunosuppressive Substance in Mice

Masahiko Fujii Biomedical Research Laboratories, Kureha Chemical Industry, Co., Ltd. 3-26-2 Hyakunin-cho Shinjuku-ku, Tokyo, 160, Japan

Norio Takahashi Biomedical Research Laboratories, Kureha Chemical Industry, Co., Ltd. 3-26-2 Hyakunin-cho Shinjuku-ku, Tokyo, 160, Japan

Takayoshi Fujii Biomedical Research Laboratories, Kureha Chemical Industry, Co., Ltd. 3-26-2 Hyakunin-cho Shinjuku-ku, Tokyo, 160, Japan

Haruhisa Hayashi Biomedical Research Laboratories, Kureha Chemical Industry, Co., Ltd. 3-26-2 Hyakunin-cho Shinjuku-ku, Tokyo, 160, Japan

Kenichi Matsunaga Biomedical Research Laboratories, Kureha Chemical Industry, Co., Ltd. 3-26-2 Hyakunin-cho Shinjuku-ku, Tokyo, 160, Japan

Takao Furusho Biomedical Research Laboratories, Kureha Chemical Industry, Co., Ltd. 3-26-2 Hyakunin-cho Shinjuku-ku, Tokyo, 160, Japan

Yoshio Omura Biomedical Research Laboratories, Kureha Chemical Industry, Co., Ltd. 3-26-2 Hyakunin-cho Shinjuku-ku, Tokyo, 160, Japan

Chikao Yoshikumi Biomedical Research Laboratories, Kureha Chemical Industry, Co., Ltd. 3-26-2 Hyakunin-cho Shinjuku-ku, Tokyo, 160, Japan

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Abstract

The effect of immunosuppressive (IS) substance obtained from cancerous ascitic fluid on tumor growth and host immunity in plasmacytoma X5563-bearing C3H/He mice is described. IS substance given in three injections, before and after tumor inoculation caused: (a) enhanced tumor growth, (b) marked reduction in survival times, (c) inhibition on Con-A response of spleen cells. Depressed natural killer (NK) activity was observed in normal and tumor-bearing mice treated with IS substance. The data presented here suggest that IS substance suppresses both humoral and cellular immunoresponsiveness and tumor cells evade immune surveillance or immunologically mediated removal.

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Tumor Growth-Promoting Effect of Immunosuppressive Substance in Mice

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Tumor Growth-Promoting Effect of Immunosuppressive Substance in Mice

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