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Original Article

The Cytolysis of Human Neuroblastoma Cells by a Natural IgM ‘Antibody’-Complement System in Pregnancy Serum

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Pages 603-611 | Published online: 11 Jun 2009
 

Abstract

Cell lines from 26 human cancers were studied for cytotoxicity when treated with normal pregnancy serum. Cytotoxicity, manifested by cell death and cytolysis, occurred in 4 of 8 neuroblastomas studied: SK-N-SH, NGP, LAN-5, and IMR-32. In NGP and SK-N-SH, evidence is presented showing that the cytotoxicity resulted from the cell-surjace binding of a natural IgM ‘antibody,’ which sensitized the neuroblastoma cells to the lytic action of complement (C). This system may be involved in a cytolytic form of spontaneous regression of neuroblastoma.

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