Scatter Factor Regulates Vascular Endothelial Cell Motility

Eliot M. Rosen Departments of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06510

William Carley Departments of Anesthesiology, Yale University School of Medicine 333 Cedar Street, New Haven, Connecticut, 06510

Itzhak D. Goldberg Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, New York, 11042

Abstract

Scatter factors (SFs) are mesenchymal cellderived cytokines which stimulate epithelial motility. SF purified from ras-transformed 3T3 cell supernatants markedly stimulated vascular endothelial cell migration at < 100 pM. Preliminary studies suggest endothelial lines with cobblestone (epithelioid) morphology respond to SF, while those lines with elongated cells do not respond. SFs may play roles in development and tissue repair.

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Scatter Factor Regulates Vascular Endothelial Cell Motility

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Scatter Factor Regulates Vascular Endothelial Cell Motility

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