Predictive Value of the Fluorescent Cytoprint Assay (FCA): A Retrospective Correlation Study of In Vitro Chemosensitivity and Individual Responses to Chemotherapy

Louis A. Leone Division of Biology and Medicine Brown University; Department of Medical Oncology, Rhode Island Hospital Providence, Rhode, Island

Patricia A. Meitner Wesearch Divlsion Analytical Biosystems Corporation Warwick, Rhode, Island

Thomas J. Myers Memorial Hospital Pawtucket, Rho, Island

William R. Grace St. Vincent's Haspital New York, New York

Walter H. Gajewski Massachussetts General Hospital

Howard J. Fingert Massachussetts General Hospital; St. Elizabeth's Hospital Boston, Massachusetts

Boris Rotman Division of Biology and Medicine Brown University

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Abstract

The potential clinical usefulness of the fluorescent cytoprint assay (FCA) was assessed retrospectively in 73 cancer patients by correlating individual tumor chemosensitivity in vitro with responses to chemotherapy. The data show that the FCA has a sensitivity of 98%, specificity of 81%, and predictive accuracies of 85% and 97% for positive and negative clinical responses, respectively.

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Predictive Value of the Fluorescent Cytoprint Assay (FCA): A Retrospective Correlation Study of In Vitro Chemosensitivity and Individual Responses to Chemotherapy

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Predictive Value of the Fluorescent Cytoprint Assay (FCA): A Retrospective Correlation Study of In Vitro Chemosensitivity and Individual Responses to Chemotherapy

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