Intracellular dCTP/ARA-CTP Ratio and the Cytotoxic Effect of ARA-C

Hajime Kawasaki Department of Pediatrics Mie, University School of Medicine Edobashi Tsu City, Mie, 514, Japan

Hiroshi Kuwabara Department of Pediatrics Mie, University School of Medicine Edobashi Tsu City, Mie, 514, Japan

Hiroki Hori Department of Pediatrics Mie, University School of Medicine Edobashi Tsu City, Mie, 514, Japan

Masamune Higashigawa Department of Pediatrics Mie, University School of Medicine Edobashi Tsu City, Mie, 514, Japan

Toshiki Ohkubo Department of Pediatrics Mie, University School of Medicine Edobashi Tsu City, Mie, 514, Japan

Minoru Sakurai Department of Pediatrics Mie, University School of Medicine Edobashi Tsu City, Mie, 514, Japan; Tumor Clinical Research Center, Mie University School of Medicine Edobashi Tsu City, Mie, 514, Japan

Abstract

In this study, the relationship between the dCTP/ara-CTP ratio and the cytotoxic effect of cytosine arabinoside (ara-C) was investigated. Intracellular levels of dNTPs and ara-CTP were analyzed by high-performance liquid chromatography. Although doubling time and intracellular dCTP levels were different in each of the cells, there was a consistent relation between the intracellular dCTP/ara-CTP ratio and the cytotoxic concentration of ara-C. These data suggest that the intracellular dCTP/ara-CTP ratio is one of the important factors for considering the cytotoxic action of ara-C.

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Intracellular dCTP/ARA-CTP Ratio and the Cytotoxic Effect of ARA-C

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