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Original Article

Analysis of the 11p13 Wilms' Tumor Suppressor Gene (WTI) in Ovarian Tumors

, , , , , & show all
Pages 393-399 | Published online: 11 Jun 2009
 

Abstract

We have examined the status of the Wilms' tumor suppressor gene (W77), residing at chromosome II band p13, in a total of 40 cancers of the female reproductive tract. Northern blot analysis revealed that the WTI gene is expressed in a large percentage of ovarian tumors (75%) analyzed. Single-strand conformation polymorphism analysis was performed on all the tumors in this study in an attempt to detect mutations within the WTI gene. Only silent mutations were detected within intron 7 of WTI using this method. Loss of heterozygosity studies were performed at the WTI locus in several ovarian tumors and revealed that in the informative cases, heterozygosity was retained.

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