Paper-based point-of-care testing for diagnosis of dengue infections

Jane Ru ChoiThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, P.R. China, ;Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia, ;Bioinspired Engineering and Biomechanics Center (BEBC), Xi’an Jiaotong University, Xi’an, P.R. China,

Jie HuThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, P.R. China, ;Bioinspired Engineering and Biomechanics Center (BEBC), Xi’an Jiaotong University, Xi’an, P.R. China,

ShuQi WangState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P.R. China, ;Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, P.R. China, ;Institute for Translational Medicine, Zhejiang University, Hangzhou, P.R. China,

Hui YangSchool of Life Sciences, Northwestern Polytechnical University, Xi’an, P.R. China, and ;Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi’an, P.R. China

Wan Abu Bakar Wan AbasDepartment of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia,

Belinda Pingguan-MurphyDepartment of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia, Correspondence[email protected]

Feng XuThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, P.R. China, ;Bioinspired Engineering and Biomechanics Center (BEBC), Xi’an Jiaotong University, Xi’an, P.R. China, Correspondence[email protected]

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Abstract

Dengue endemic is a serious healthcare concern in tropical and subtropical countries. Although well-established laboratory tests can provide early diagnosis of acute dengue infections, access to these tests is limited in developing countries, presenting an urgent need to develop simple, rapid, and robust diagnostic tools. Point-of-care (POC) devices, particularly paper-based POC devices, are typically rapid, cost-effective and user-friendly, and they can be used as diagnostic tools for the prompt diagnosis of dengue at POC settings. Here, we review the importance of rapid dengue diagnosis, current dengue diagnostic methods, and the development of paper-based POC devices for diagnosis of dengue infections at the POC.

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Declaration of interest

The authors report no declarations of interest.

This work was financially supported by the Major International Joint Research Program of China (11120101002), the Key (Key grant) Project of Chinese Ministry of Education (313045), and the International Science & Technology Cooperation Program of China (2013DFG02930). J.R.C., B.P.-M., and W.A.B.W.A. received funding from the Ministry of Higher Education (MOHE), Government of Malaysia under the high impact research (UM.C/HIR/MOHE/ENG/44). F.X. was also partially supported by the China Young 1000-Talent Program and Program for New Century Excellent Talents in University (NCET-12–0437).

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Paper-based point-of-care testing for diagnosis of dengue infections

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