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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 30, 2013 - Issue 7
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Research Article

Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans

, , , , , & show all
Pages 901-909 | Received 17 Dec 2012, Accepted 04 Mar 2013, Published online: 05 Jun 2013
 

Abstract

This study investigated the impact of sleep deprivation on the human circadian system. Plasma melatonin and cortisol levels and leukocyte expression levels of 12 genes were examined over 48 h (sleep vs. no-sleep nights) in 12 young males (mean ± SD: 23 ± 5 yrs). During one night of total sleep deprivation, BMAL1 expression was suppressed, the heat shock gene HSPA1B expression was induced, and the amplitude of the melatonin rhythm increased, whereas other high-amplitude clock gene rhythms (e.g., PER1-3, REV-ERBα) remained unaffected. These data suggest that the core clock mechanism in peripheral oscillators is compromised during acute sleep deprivation.

Acknowledgements

The authors thank Daniel Barrett and the Surrey CRC medical, clinical, and research teams for their help with the clinical study.

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