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Abstract
Circadian rhythm disturbances overlap between psychotic disorders, e.g. schizophrenia, and major depression. We hypothesized that circadian gene variants previously associated with unipolar depression would be overrepresented also in patients with psychotic disorder. Six genetic polymorphisms in ARNTL, PER2 and CRY2 were genotyped in 566 schizophrenia spectrum disorder patients and 926 controls. The rs2290036-C variant of ARNTL was over-represented in psychosis patients, and the variants rs934945-G and rs10462023-G of PER2 were associated with a more severe psychotic disorder. The directions of these genetic associations were in line with those previously identified for depression.
Acknowledgements
The authors would like to thank Carina Schmidt and Dr. Eric Olsson for clinical data handling, and all the participants and staff in the PART and SMRP study.
Declaration of interest
This work was supported by the Swedish Research Council (2009-5546 YF, 2010-3631 CL, 2011-4807 MS), the China Scholarship Council (CSC), the Karolinska Institutet’s Faculty Funds and the regional agreement on medical training and clinical research between Stockholm County Council and Karolinska Institutet (20060100 UÖ, 20080022 UÖ and 20110560 CL, a KIgene core grant 20120802 MS), Swedish Brain Foundation (MS) the Söderström-Königska Foundation and the Fredrik and Ingrid Thuring’s Foundation.