No Orcadian Rhythms of Serotoninergic, Alpha-, Beta-Adrenergic and Imipramine Binding Sites in Rat Brain Regions

Andrea Di Lauro Department of Psychiatry Second Medical School, University of Naples, Naples, Italy

Clemente Patrizio Giannini Department of Psychiatry Second Medical School, University of Naples, Naples, Italy

Giovanni Muscettola Department of Psychiatry Second Medical School, University of Naples, Naples, Italy

Anna Maria Greco Institute of Human Physiological Science, Second Medical School, University of Naples, Naples, Italy

Pietro de Franciscis Institute of Human Physiological Science, Second Medical School, University of Naples, Naples, Italy

Abstract

B_max values of the specific binding of [³H]-WB 4101, [³H]-dihydroalprenolol, [³H]-spiperone and [³H]-imipramine to various rat brain regions were determined at 4 hr intervals over 24 hr under circadian conditions. No significant circadian rhythm of binding sites number was found for any receptor investigated in cerebral cortex, hypothalamus or brain stem. Some methodological issues are discussed.

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No Orcadian Rhythms of Serotoninergic, Alpha-, Beta-Adrenergic and Imipramine Binding Sites in Rat Brain Regions

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No Orcadian Rhythms of Serotoninergic, Alpha-, Beta-Adrenergic and Imipramine Binding Sites in Rat Brain Regions

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