Effect of Rubidium on the Course of Illness and the Orcadian Rectal Temperature in a 66-Year-Old Depressive Woman

Abstract

Rubidium (Rb*) has an antidepressive effect and shortens the circadian period in animals, whereas Li*, another alcalic metal, lengthens it. When we treated a depressive Li* nonresponder with Rb*, we found an improvement of depression as well as a phase advance of the temperature rhythm in relation to the rest-activity rhythm.