Biochemical Markers and Bone Mineral Density in Patients with Hip Fractures in Men

Abstract

The purpose of this study was to determine whether males with hip fractures have associated decreased gonadal function. Second void urine and serum samples were obtained from 25 male hip fracture patients (mean age±SD, 78.5±5.9 years) and 19 age- and gender-matched controls (77.6±6.2 years). Serum levels of luteinizing hormone (LH), total testosterone (Te), total estradiol (E₂), dehydroepiandrosterone sulfate (DHEAS), 1,25(OH)₂D₃, N-mid osteocalcin (OC_N-mid). type I collagen degradation products (S-CTx) and urinary levels of pyridinoline (Pyr), deoxypyridinoline (Dpyr) and type I collagen degradation products (U-CTx) were measured. Bone mineral density (BMD) of the L2-4 spine, femoral neck, trochanter. Ward's triangle, distal one third portion of the radius and ultradistal radius were also measured in the fracture group. Serum levels of LH, E₂, Te, DHEAS, 1,25(OH)₂D₃ and OC_N-mid in the fracture group were not statistically different from those in the control group. Levels of urinary Pyr, CTx and S-CTx in the fracture group increased significantly compared with those in the control group. In the fracture group, serum levels of Te correlated positively with distal one third portion of the radius BMD and ultradistal radius BMD. U-CTx and S-CTx correlated negatively with all the BMD measurement sites in the hip region and with the radius BMD. An imbalance between bone resorption and bone formation was evident in male hip fracture patients. However, male patients with hip fractures did not show associated decreased gonadal function in this study.